Click Here to return To Results

 

Strong Clustering and Stereotyped Nature of Notch3 Mutations, in CADASIL Patients Lancet 350:1511-1515, 14901997., Joutel,A.,et al, 1997 See this aricle in Pubmed Article Abstract Because of the strong clustering and highly stereotyped nature of the pathogenetic mutations detected in CADASIL patients,an easy and reliable diagnostic test for CADASIL is feasible.The findings suggest that aberrant dimerisation of Notch3,due to abnormal disulphide bridging with another Notch3 molecule or with another protein,may be involved in the pathogenesis of this disorder.

Related Tags

(click to filter results - removes previous filter) cerebral autosomal dominate arteriopathy with subcortical infarction and leukoencephalopathy cerebral infarction cerebrovascular accident cerebrovascular accident,familial occurrence familial gene gene mutation genetic linkage genetic neurologic disorders genetic screening misdiagnosis MRI MRI,abnormal multiple sclerosis multiple sclerosis,differential diagnosis of multiple sclerosis,misdiagnosis neurologic disease,diagnoses of

Click Here to return To Results